I received a comment from Holly asking if I had problems with the hybrid inks smearing if I heat set them first. I had never heat my hybrid inks before so I thought I would do a side-by-side comparison to see if it helps.
EXAMPLE #1

On the above example (and my previous card), I used a heavy cardstock that I think is around 140lb. weight. The chick image was stamped in Dark Chocolate hybrid ink in the upper left corner and heat set. Then I stamped the image again in the upper right corner using the same ink with out heat setting it. As you can see in the example, the heat set image did not bleed as much as the non-heat set image.
I also stamped the image using Memento Tuxedo Black ink – heat setting the one on the left. The only colors that seemed to effect the ink of the non heat set image was E51, which I used on the birds tail. But to make see if paper type caused a difference in the bleeding, I also experimented on another cardstock.
EXAMPLE #2

On this example, I stamped my images onto 120lb. Pure Luxury White cardstock from Gina K. Designs. Again, I stamped the upper left image in Dark Chocolate hybrid ink and heat set it while the image in the upper right was not heat set. On this example there was much less noticeable bleed on the non-heat set example – just a bit where I blended BG32 and BG49 for his scarf.
As with the first example I stamped the images on the bottom using Memento Tuxedo Black ink for comparison. There was no noticeable difference in the heat set vs. non-heat set images.
CONCLUSION:
When using Copic markers with hybrid inks, heat setting the ink may help reduce bleeding. Also paper type will make a difference in the amount of bleeding that occurs. The Pure Luxury cardstock from example #2 has a smooth coating on it that doesn’t allow it to absorb as much ink, unlike the uncoated cardstock I used in example #1, so you are going to incur less bleeding.
The best way to find out if a certain products work together is to test them out. Don’t be afraid to sit down and toy around with different combinations of inks and paper. Who knows, you may create a new technique!